Closed System Transfer Devices Market By Type (Needleless Systems and Membrane-to-membrane Systems), By Component (Bag Spikes, Female Components, Male Luers, Vial Access Devices, and Others), By Closing Mechanism (Click-to-lock Systems, Luer-lock Systems, Color-to-color Alignment Systems, and Push-to-turn Systems), By Technology (Compartmentalized Devices, Air Cleaning/Filtration Devices, and Diaphragm-Based Devices), By End-user (Oncology Centers, Hospitals & Clinics, and Others), Region and Companies – Industry Segment Outlook, Market Assessment, Competition Scenario, Trends and Forecast 2024-2033

Report Overview

The Closed System Transfer Devices Market size is expected to be worth around USD 5.0 billion by 2033 from USD 1.1 billion in 2023, growing at a CAGR of 16.4% during the forecast period 2024 to 2033.

Growing demand for closed system transfer devices (CSTDs) is being driven by the increasing need to protect healthcare workers and patients from hazardous drug exposure, particularly in oncology and other high-risk drug treatments. CSTDs ensure the safe transfer of medication, reducing the risk of contamination and exposure during drug preparation and administration.

These devices find applications in chemotherapy, immunotherapy, and antiviral drug delivery, offering enhanced safety and compliance with stringent healthcare regulations. In February 2022, Zydus Cadila began supplying its needle-free anti-COVID vaccine, ZyCoV-D, to the Indian government, underscoring the role of advanced delivery systems in preventing contamination and improving safety.

The market continues to grow as healthcare providers seek solutions that ensure sterile environments and minimize occupational hazards. Recent trends include the development of more user-friendly, cost-effective CSTDs and increasing regulatory emphasis on safety, creating opportunities for innovation and market expansion.

Key Takeaways

• In 2023, the market for Closed System Transfer Devices generated a revenue of USD 1.1 billion, with a CAGR of 16.4%, and is expected to reach USD 5.0 billion by the year 2033.
• The type segment is divided into needleless systems and membrane-to-membrane systems, with membrane-to-membrane systems taking the lead in 2023 with a market share of 56.8%.
• Considering component, the market is divided into bag spikes, female components, male luers, vial access devices, and others. Among these, vial access devices held a significant share of 37.5%.
• Furthermore, concerning the closing mechanism segment, the market is segregated into click-to-lock systems, luer-lock systems, color-to-color alignment systems, and push-to-turn systems. The color-to-color alignment systems sector stands out as the dominant player, holding the largest revenue share of 23.5% in the Closed System Transfer Devices market.
• The technology segment is segregated into compartmentalized devices, air cleaning/filtration devices, and diaphragm-based devices, with the diaphragm-based devices segment leading the market, holding a revenue share of 52.1%.
• Considering end-user, the market is divided into oncology centers, hospitals & clinics, and others. Among these, hospitals & clinics held a significant share of 61.5%.
• North America led the market by securing a market share of 40.1% in 2023.

Type Analysis

The membrane-to-membrane systems segment led in 2023, claiming a market share of 56.8% owing to their superior ability to prevent contamination and reduce hazardous drug exposure. These systems are particularly favored for handling toxic medications like chemotherapy drugs, as they provide a double membrane barrier that ensures the safe transfer of medications between containers.

Rising concerns over healthcare worker safety, coupled with stringent regulations regarding the handling of hazardous drugs, are projected to further boost demand for membrane-to-membrane systems. Additionally, their ease of use and compatibility with a variety of drug containers are likely to support the segment’s continued expansion in healthcare settings.

Component Analysis

The vial access devices held a significant share of 37.5% due to the increasing demand for safer drug transfer processes. These devices enable healthcare professionals to draw medication from vials without compromising sterility or risking exposure to hazardous drugs. The rising prevalence of chronic diseases, such as cancer, which requires frequent handling of toxic medications, is projected to drive the need for vial access devices.

Enhanced safety features, such as integrated filters and easy-to-use designs, further contribute to their growing adoption. The push for stricter safety standards in drug administration is also likely to support the segment’s growth.

Closing Mechanism Analysis

The color-to-color alignment systems segment had a tremendous growth rate, with a revenue share of 23.5% owing to its user-friendly design, which simplifies the drug transfer process. These systems allow healthcare workers to easily align components, ensuring secure and accurate connections, and reducing the risk of medication errors.

The increasing focus on minimizing hazardous drug exposure in clinical settings is likely to drive the adoption of these systems. Additionally, the color-coded design enhances the visual confirmation of proper alignment, improving safety and efficiency during drug preparation and administration. This segment’s growth is further anticipated as demand for intuitive, error-reducing technologies rises.

Technology Analysis

The diaphragm-based devices segment grew at a substantial rate, generating a revenue portion of 52.1% due to their effective contamination prevention and ability to maintain a sealed environment during drug transfer. Diaphragm-based systems minimize the risk of hazardous drug exposure by providing a physical barrier that prevents leaks or spills.

The growing use of these devices in oncology, where safe handling of toxic medications is critical, is expected to drive demand. Additionally, their increasing adoption in other high-risk environments, such as intensive care units, is likely to contribute to the segment’s expansion. Technological advancements in diaphragm materials and designs also support their growing use.

End-user Analysis

The hospitals & clinics held a significant share of 61.5% due to the rising demand for safe drug handling protocols in large healthcare settings. Hospitals and clinics are often the primary centers for administering hazardous drugs, such as chemotherapy, which increases the need for secure transfer systems.

Growing regulatory requirements for drug safety and the adoption of closed systems to protect healthcare workers and patients from exposure to toxic substances are likely to drive this segment’s growth. Additionally, the increasing prevalence of chronic diseases requiring frequent hospital treatments is anticipated to further boost demand for closed system transfer devices in these facilities.

Key Market Segments

By Type

• Needleless Systems
• Membrane-to-membrane Systems

By Component

• Bag Spikes
• Female Components
• Male Luers
• Vial Access Devices
• Others

By Closing Mechanism

• Click-to-lock Systems
• Luer-lock Systems
• Color-to-color Alignment Systems
• Push-to-turn Systems

By Technology

• Compartmentalized Devices
• Air Cleaning/Filtration Devices
• Diaphragm-Based Devices

By End-user

• Oncology Centers
• Hospitals & Clinics
• Others

Drivers

Growing Prevalence of Cancer

The increasing prevalence of cancer drives the demand for closed system transfer devices (CSTDs) in healthcare settings, as these devices help minimize exposure to hazardous drugs, especially during chemotherapy. According to the American Cancer Society, approximately 1.9 million new cancer cases were diagnosed in the United States in 2021, along with 608,570 deaths from the disease. As the number of cancer patients rises, so does the need for safe and efficient drug transfer systems to protect healthcare workers and patients from toxic medications.

CSTDs have gained significant acceptance in hospitals and oncology centers as they improve safety standards and reduce contamination risks during cancer treatments, driving market growth.

Restraints

High Cost of Implementing CSTDs

Rising costs associated with implementing closed-system transfer devices hamper market growth, particularly in smaller healthcare facilities. CSTDs require substantial investments in equipment, training, and maintenance, which can create financial barriers for institutions with limited budgets. The complexity of integrating these devices into existing workflows further complicates adoption, driving up operational costs.

These financial challenges are anticipated to impede widespread adoption, especially in developing regions where healthcare budgets are constrained. While the safety benefits are well-recognized, the high initial costs limit access to CSTDs, particularly in resource-limited settings, slowing overall market expansion.

Opportunities

Increasing Demand for Needle-free Technology

Increasing demand for needle-free technology creates significant opportunities for the closed system transfer devices market. As healthcare providers seek to reduce the risks of needlestick injuries and cross-contamination, the adoption of needle-free systems is anticipated to rise. For instance, in May 2022, Pulse NeedleFree Systems introduced a disposable line of needle-free livestock vaccination devices, demonstrating the growing shift towards safer, more efficient drug delivery methods.

While initially developed for veterinary use, similar innovations in human healthcare are expected to drive demand for needle-free CSTDs, offering safer alternatives for handling hazardous drugs. This trend is projected to propel market growth as healthcare providers increasingly adopt these advanced technologies.

Impact of Macroeconomic / Geopolitical Factors

Macroeconomic and geopolitical factors significantly affect the closed system transfer devices (CSTD) market, shaping both opportunities and risks. Economic slowdowns in key regions may reduce healthcare spending, impacting the adoption of advanced medical technologies like CSTDs. Additionally, geopolitical tensions and trade restrictions can disrupt the supply chain, leading to increased costs and delays in manufacturing.

However, rising government regulations focused on healthcare worker safety and hazardous drug handling drive the demand for CSTDs. Furthermore, expanding healthcare infrastructure in emerging markets creates new opportunities for growth. Despite challenges, the market continues to grow due to regulatory support and technological advancements.

Latest Trends

Rising Trend of Collaborations and Acquisitions

Rising collaborations and acquisitions are driving growth in the closed system transfer devices market. Companies are increasingly joining forces to expand their market reach and improve product offerings. In March 2022, Vygon SA, a French medical device company, acquired Macatt Medica, a distributor in Lima, Peru, which strengthened Vygon’s presence in South America.

This acquisition is anticipated to boost Vygon’s product distribution, including closed system transfer devices, across the region. As more companies collaborate and acquire smaller firms, the market is projected to see increased innovation and better access to emerging markets, fueling long-term growth and development.

Regional Analysis

North America is leading the Closed System Transfer Devices Market

North America dominated the market with the highest revenue share of 40.1% owing to heightened awareness of safety protocols in handling hazardous drugs and increasing regulatory requirements for healthcare settings. The rise in cancer and chronic disease treatments, which often involve hazardous medications, has amplified the demand for safer drug administration practices. Furthermore, healthcare facilities have prioritized minimizing exposure risks for healthcare workers and patients alike.

A pivotal development occurred in March 2022, when Baxter International entered into an agreement with a subsidiary of Pfizer Inc. to acquire rights to Zosyn, a premixed frozen piperacillin-tazobactam product. This agreement highlights the importance of innovative drug delivery solutions that ensure safe handling during administration. The overall commitment to enhancing patient and staff safety in hospitals and clinics has significantly contributed to the robust growth of the market in North America.

The Asia Pacific region is expected to experience the highest CAGR during the forecast period

Asia Pacific is expected to grow with the fastest CAGR owing to increasing investments in healthcare infrastructure and a growing emphasis on patient safety. Countries like China and India are projected to lead this growth, spurred by the rising prevalence of cancer and other chronic diseases that require complex medication regimens.

Healthcare providers are anticipated to adopt more stringent safety measures, including the implementation of closed systems to mitigate exposure risks associated with hazardous drugs. Moreover, ongoing regulatory reforms aimed at improving healthcare quality and safety are likely to further enhance market prospects. As pharmaceutical companies innovate in drug delivery methods, the demand for effective and safe transfer devices is projected to rise, making a significant impact on the region’s healthcare landscape.

Key Regions and Countries

• North America
  • US
  • Canada
• Europe
  • Germany
  • France
  • The UK
  • Spain
  • Italy
  • Russia
  • Netherland
  • Rest of Europe
• Asia Pacific
  • China
  • Japan
  • South Korea
  • India
  • Australia
  • New Zealand
  • Singapore
  • Thailand
  • Vietnam
  • Rest of APAC
• Latin America
  • Brazil
  • Mexico
  • Rest of Latin America
• Middle East & Africa
  • South Africa
  • Saudi Arabia
  • UAE
  • Rest of MEA

Key Players Analysis

The major players in the Closed System Transfer Devices market are actively engaged in the development and introduction of innovative products, as well as implementing strategic initiatives aimed at enhancing their competitive positioning. Key players in the closed system transfer devices market focus on enhancing product safety and efficiency by developing advanced contamination-prevention technologies.

They collaborate with hospitals and oncology centers to integrate these devices into chemotherapy and hazardous drug administration protocols. Strategic partnerships with healthcare distributors help expand their market presence and streamline product availability. Many companies invest in extensive training programs for healthcare professionals to promote safe handling and usage. Additionally, they pursue global expansion by targeting regions with increasing demand for safety measures in drug handling and administration.

Top Key Players in the Closed System Transfer Devices Market

• Yukon Medical
• Victus, Inc.
• Teva Pharmaceutical Industries Ltd.
• ICU Medical, Inc.
• EQUASHIELD
• CodanMedizinischeGeräte GmbH & Co Kg
• Braun Melsungen
• Becton, Dickinson, and Company
• Baxter International Inc.

Recent Developments

• In October 2023, EQUASHIELD reinforced its commitment to protecting healthcare professionals from hazardous drug exposure by advancing its automated compounding solutions and closed-system transfer devices (CSTDs). The EQUASHIELD Syringe Unit recently received additional FDA clearance for full-volume utilization, offering a cost-effective solution for medication compounding and administration. With its closed-back design and bonded connector, the Syringe Unit mitigates risks of vapor escape and plunger contamination more effectively than competitor systems. This innovation is pivotal for the growth of the closed system transfer devices market, enhancing safety standards and reducing exposure to hazardous drugs.
• In January 2022, ICU Medical Inc. completed the acquisition of Smiths Medical, a subsidiary of Smiths Group plc, which provides vascular access, ambulatory infusion devices, and syringes. By integrating these products into its existing portfolio, ICU Medical strengthened its position in the infusion therapy sector, contributing to the expansion of the closed system transfer devices market by offering a wider range of complementary devices that address drug administration and safety in healthcare settings.

Report Scope