The Global Nattokinase Market Size, Share, And Business Benefits By Type (Upto 10000 Fu/g, 10001-20000 Fu/g, Above 20001 Fu/g),By Application (Nutraceuticals, Food Additives, Pharmaceuticals, Others), By Distribution Channel(Online, Offline), By Region and Companies - Industry Segment Outlook, Market Assessment, Competition Scenario, Trends, and Forecast 2025-2034

Report Overview

The Global Nattokinase Market is expected to be worth around USD 68.4 million by 2034, up from USD 38.9 million in 2024, and is projected to grow at a CAGR of 5.8% from 2025 to 2034. North America’s Nattokinase Market achieved 45.20% dominance, with a market value of USD 17.6 Mn.

Nattokinase is a natural enzyme extracted from “natto,” a traditional Japanese food made by fermenting soybeans with Bacillus subtilis. This enzyme has attracted global attention due to its potential role in supporting cardiovascular health. It is believed to aid in breaking down fibrin, a protein involved in blood clot formation, thereby supporting healthy blood circulation and heart wellness. According to an industry report, Nutraceutical ingredient start-up Zeus Hygia secures $2.5 million in funding.

The Nattokinase market refers to the global trade and consumption of this enzyme across dietary supplements, functional foods, and nutraceutical applications. With rising consumer focus on preventive healthcare and natural remedies, the market is gradually expanding in regions where plant-based supplements and traditional remedies are gaining popularity. According to an industry report, A brand producing stick-on supplements gained ₹50 lakhs in investment on Shark Tank India, highlighting their potential.

One major growth factor for this market is the increasing prevalence of cardiovascular diseases worldwide, which are the leading cause of death according to the World Health Organization. As people seek safer, natural alternatives to support heart health, demand for enzymes like Nattokinase is steadily increasing.

Demand is also fueled by the growing interest in functional foods and supplements that improve overall well-being. Health-conscious consumers are shifting toward natural products that not only provide nutrition but also carry therapeutic benefits, making nattokinase-based products an appealing choice. According to an industry report, Gut health-driven nutraceutical company The Good Bug successfully raised ₹100 crore.

An opportunity lies in wider awareness and regulatory approvals across global markets. Educational campaigns on preventive health, along with governments encouraging natural health solutions, can significantly expand adoption. Future innovation in supplement formulations and broader distribution channels will further create room for growth in the Nattokinase market. According to an industry report, HealthKart obtained $153 million in funding from ChrysCapital and Motilal Oswal Alternates.

Key Takeaways

• The Global Nattokinase Market is expected to be worth around USD 68.4 million by 2034, up from USD 38.9 million in 2024, and is projected to grow at a CAGR of 5.8% from 2025 to 2034.
• In 2024, up to 10000 Fu/g the nattokinase market by type reached a 44.8% share.
• Nattokinase Market by nutraceuticals application accounted for a 43.2% significant share.
• Offline distribution dominated the nattokinase market channels with a 76.9% share.
• The strong demand in North America, holding 45.20% share, is valued at USD 17.6 Mn.

By Type Analysis

By Type, Nattokinase Market shows up to 10000 Fu/g, capturing 44.8% share.

In 2024, up to 10000 Fu/g held a dominant market position in By Type Analysis segment of the Nattokinase Market, with a 44.8% share. This segment reflects the strong consumer preference for moderate enzyme potency that balances both affordability and effectiveness.

Nattokinase with activity levels up to 10000 Fu/g is widely chosen in dietary supplements and functional foods due to its suitability for daily consumption without posing concerns over excessive dosage. Consumers, particularly in regions where natural health products are growing in popularity, are opting for this range as it aligns with preventive healthcare trends and lifestyle-based supplementation.

The dominance of this segment is further linked to its accessibility and versatility across product formulations. Manufacturers find up to 10000 Fu/g Nattokinase convenient for encapsulation, blending with other nutraceuticals, and fortification into functional beverages and health-supporting products.

Additionally, this range addresses the needs of a broader demographic, including older adults and those seeking safe, plant-based solutions for cardiovascular health. With increasing awareness about natural enzymes and rising adoption of nutraceuticals, this strength category is expected to maintain its lead in the coming years.

By Application Analysis

By Application, Nattokinase Market highlights Nutraceuticals leading strongly with 43.2% market share.

In 2024, Nutraceuticals held a dominant market position in By Application Analysis segment of the Nattokinase Market, with a 43.2% share. This leading position highlights the growing integration of Nattokinase into health supplements and functional products designed to support cardiovascular wellness and overall preventive healthcare.

The nutraceuticals segment has gained traction as consumers increasingly prefer natural bioactive compounds over synthetic alternatives, with nattokinase being recognized for its role in maintaining healthy blood flow and reducing risks associated with clot formation.

The 43.2% share demonstrates how nutraceuticals have become the most important channel for Nattokinase consumption, especially in regions where dietary supplements are part of everyday routines. The convenience of capsules, tablets, and powder forms makes this application highly adaptable to consumer lifestyles, while also aligning with the rising trend of self-care and proactive health management.

The segment’s strength also comes from growing distribution through pharmacies, online platforms, and health food stores, which has expanded accessibility and awareness.

By Distribution Channel Analysis

By Distribution Channel, the Nattokinase Market demonstrates Offline channels dominating with 76.9% share.

In 2024, Offline held a dominant market position in the By Distribution Channel Analysis segment of the Nattokinase Market, with a 43.2% share. This dominance reflects the continued trust and reliance consumers place on physical retail outlets, including pharmacies, health food stores, and specialty supplement shops.

The offline channel provides a direct and tangible purchasing experience, allowing customers to seek advice from health professionals or store experts before selecting Nattokinase products. This in-person interaction plays a crucial role in driving confidence, particularly for first-time buyers of dietary supplements.

The 43.2% share also highlights the offline channel’s ability to build credibility through visibility and established networks. Pharmacies and wellness centers remain critical points of sale, especially in markets where consumers prefer to verify product authenticity and safety before purchase.

Additionally, attractive in-store promotions, bundled offers, and consultations have supported the channel’s stronghold. For many regions, offline sales continue to dominate due to limited internet penetration and the preference for traditional shopping practices in healthcare-related products.

Key Market Segments

By Type

• Up to 10000 Fu/g
• 10001-20000 Fu/g
• Above 20001 Fu/g

By Application

• Nutraceuticals
• Food Additives
• Pharmaceuticals
• Others

By Distribution Channel

• Online
• Offline

Driving Factors

Rising Heart Health Awareness Drives Market Growth

One of the strongest driving factors for the Nattokinase market is the increasing awareness about heart health across the world. Cardiovascular diseases remain the leading cause of death globally, and people are now looking for natural ways to protect their hearts and improve blood circulation.

Nattokinase, an enzyme from fermented soybeans, is gaining recognition for its potential role in breaking down fibrin, which helps reduce the risk of blood clots. With busy lifestyles, unhealthy diets, and stress, more people are turning to supplements to manage long-term wellness.

This trend is further supported by educational campaigns and a growing preference for plant-based solutions, making nattokinase a trusted choice in preventive healthcare and boosting its demand worldwide.

Restraining Factors

Expanding Global Reach Through Preventive Health Solutions

A major growth opportunity for the Nattokinase market lies in its potential expansion across global preventive healthcare sectors. As consumers in both developed and emerging economies become more proactive about managing their health, the demand for natural and effective supplements is growing rapidly.

Nattokinase, known for supporting cardiovascular health and healthy blood circulation, fits well into this trend. The opportunity is especially strong in regions where lifestyle diseases such as hypertension and cholesterol are rising, creating a need for accessible and natural interventions.

With increased awareness campaigns, supportive regulations for nutraceuticals, and the rise of global distribution networks, companies can position Nattokinase as a mainstream wellness product, unlocking strong growth opportunities in the years ahead.

Growth Opportunity

Limited Clinical Evidence Restrains Wider Market Adoption

One key restraining factor for the Nattokinase market is the limited availability of large-scale clinical evidence to fully support its health claims. While early research and traditional use highlight potential benefits for cardiovascular wellness, many healthcare professionals remain cautious about recommending it due to insufficient long-term studies.

This lack of extensive scientific backing can slow down consumer trust and regulatory approvals in some regions. As supplements are often judged on proven safety and effectiveness, the gap in robust clinical trials makes adoption slower compared to other well-established nutraceuticals.

Until stronger evidence and global standard guidelines are established, this factor may continue to limit the pace of market expansion despite growing interest in natural health solutions.

Latest Trends

Rising Demand For Plant-Based Natural Heart Supplements

A key trend shaping the Nattokinase market is the rising demand for plant-based and natural supplements that support heart health. Consumers are becoming more aware of the side effects linked to synthetic drugs and are turning toward natural enzymes like Nattokinase, derived from fermented soybeans.

This trend is also fueled by the global shift to clean-label and vegan products, where buyers prefer supplements free from artificial ingredients. Nattokinase fits well into this movement, as it offers both natural origin and potential cardiovascular benefits.

The popularity of preventive health practices, combined with wider availability through pharmacies, health stores, and online channels, makes this trend one of the strongest forces driving innovation and shaping product development in the market.

Regional Analysis

In 2024, North America dominated the Nattokinase Market with a 45.20% share, reaching USD 17.6 Mn.

The Nattokinase Market demonstrates significant regional diversity, with North America emerging as the dominant region in 2024. Holding a commanding 45.20% share, equivalent to USD 17.6 million, North America leads the market due to its well-established nutraceutical industry, rising prevalence of cardiovascular diseases, and growing consumer awareness about preventive healthcare.

The region benefits from a strong demand for natural, plant-based supplements, where Nattokinase is increasingly recognized for its role in supporting heart health and circulation. Factors such as higher healthcare spending, a well-informed population, and a preference for evidence-backed nutraceuticals further strengthen the region’s position.

Additionally, widespread availability through offline and online distribution channels ensures easy consumer access, supporting consistent growth. While other regions such as Europe, Asia Pacific, the Middle East & Africa, and Latin America are also witnessing expanding interest in Nattokinase, North America’s robust healthcare infrastructure and advanced supplement consumption habits have positioned it as the leading market.

With its 45.20% dominance, North America continues to set the pace for global adoption, indicating its critical role in shaping overall industry growth and highlighting the importance of this region in driving long-term market opportunities for Nattokinase worldwide.

Key Regions and Countries

• North America
  • US
  • Canada
• Europe
  • Germany
  • France
  • The UK
  • Spain
  • Italy
  • Rest of Europe
• Asia Pacific
  • China
  • Japan
  • South Korea
  • India
  • Australia
  • Rest of APAC
• Latin America
  • Brazil
  • Mexico
  • Rest of Latin America
• Middle East & Africa
  • GCC
  • South Africa
  • Rest of MEA

Key Players Analysis

In 2024, Japan Bio Science Laboratory Co., Ltd. continues to stand out as a pioneering company in the Nattokinase market. With decades of expertise in fermentation science, the company has built a reputation for producing high-quality and clinically researched Nattokinase. Their strong foundation in Japanese traditional fermentation methods gives them an edge in authenticity and product credibility, which resonates well with both domestic and international consumers seeking reliable cardiovascular health solutions.

Creative Enzymes, on the other hand, has been contributing significantly to innovation in enzyme technology, including Nattokinase. The company is recognized for its advanced biotechnological capabilities, which allow it to develop specialized enzyme products tailored to the nutraceutical and pharmaceutical industries. By leveraging enzyme engineering and research-based formulations, Creative Enzymes is playing a critical role in expanding the applications of Nattokinase into diverse product forms, making it more adaptable for global supplement manufacturers.

Bioven Ingredients is another notable player shaping the market with its focus on offering high-quality nutraceutical ingredients, including Nattokinase. The company emphasizes natural and safe bioactive compounds, aligning with the rising consumer preference for clean-label and plant-based products. By strengthening its ingredient portfolio and expanding its supply capabilities, Bioven Ingredients is enhancing its role as a dependable supplier in the value chain of Nattokinase-based supplements.

Top Key Players in the Market

• Japan Bio Science Laboratory Co., Ltd.
• Creative Enzymes
• Bioven Ingredients
• Eiffel Biotech
• Daiwa Pharmaceutical Co. Ltd.
• Contek Life Science Co., Ltd.
• NutraCap Labs
• Infinita Biotech Private Limited
• PHARMANAGER INGREDIENTS
• GeneFerm Biotechnology Co., Ltd.

Recent Developments

• In July 2025, GeneFerm launched new functional probiotic products—GFRena2®, TestoPro, and AquaSoiivon—in collaboration with National Taiwan University. These products focus on circulatory support, metabolism, and soy isoflavone bioavailability, but notably do not involve Nattokinase.
• In April 2021, Eiffel Biotech specializes in producing high-quality Nattokinase—referred to as BSNK66®—with activity levels ranging from 2,000 to 50,000 FU/g. Their enzyme is developed under stringent standards, holding certifications like ISO 22000 and HACCP, and regularly undergoes third-party testing by institutions such as TAF and TFDA labs.

Report Scope