Global HLA Typing Market By Product (Instruments, Reagents & Consumables, Software, and Services), By Technology (Molecular Assay, Non-Molecular Assay, and Sequenced-based Molecular Assay), By Application (Diagnostics and Research), By End-User, By Region and Companies - Industry Segment Outlook, Market Assessment, Competition Scenario, Trends, and Forecast 2023-2032

Report Overview

The HLA Typing Market size is expected to be worth around USD 2.2 Billion by 2032 from USD 1.2 Billion in 2022, growing at a CAGR of 6.4% during the forecast period from 2023 to 2032.

Human leukocyte antigen (HLA) is used to match patients as well as donors for bone marrow or blood transplants; human leukocyte antigen is a protein initiated on most of the cells in the body. The immune system uses this marker to determine which cells are acceptable in the body and which cells are foreign. This typing is generally used in medical settings such as to match the donor and recipient, and before an organ transplant, HLA types are close as possible to decrease the risk of rejection.

It is also useful in the diagnosis and management of autoimmune diseases, such as rheumatoid arthritis, and in defining weaknesses in certain diseases or infections.  Human leukocyte antigens are also defined as a method in which tissue or blood samples are tested for human leukocyte antigens. This system plays a major role in the body’s immune response to foreign substances. This antigen is a complex of genes on chromosome 6 in humans, which encode cell-surface proteins answerable for the regulation of the immune system.

Key Takeaways

• As regards products, the reagents & consumables segment achieved a revenue share of 55.3% in 2022.
• In terms of technology, the molecular assay segment generated the most revenue with market share amounting to 52%.
• In 2022, diagnostics accounted for the largest revenue share of the market by application.
• Based on End Users, the hospitals & transplant centers segment dominated the market, and it is forecast to grow at a fastest compound annual growth rate between 2023 and 2032.
• Regionally, North America was the largest contributor to the market, with a market share of 47.9%.
• Europe contributesd heavily to the market as well and held a market share of 28.6%.
• Asia Pacific market is expected to register a CAGR of 8.6% throughout the forecast.

By Product Analysis

Reagents & Consumables Segments to Witness Significant Growth

The global HLA typing market is categorized into instruments, services, software, and reagents & consumables. The reagents & consumables segment accounted for the largest market revenue share of 55.3% in 2022.  The reagents & consumables are balancing products in a range of diagnostic test kits, which includes HLA typing, that are used to improve the precision and speed of analyzes.  In 2021, according to the annual report statement of Thermo Fisher Scientific Inc., the significant players of reagents were from the healthcare, pharmaceutical, and clinical industry.

The instruments segment is dominating during the historical period and is estimated to hold the second-largest market share, owing to the increasing use of developed instruments, which benefits in providing better and more accurate results.

By Technology Analysis

The Molecular Assay Segment Dominates the Market Growth of the HLA Typing Market

Based on technology, the global HLA typing market is classified into molecular assay, sequenced–based molecular assay, and non-molecular assay. The molecular assay dominated segment with the highest market revenue share of 52% in 2022. Molecular techniques such as hugely parallel sequencing or probe base hybridization approaches are the maximum perform the method in HLA typing. Molecular typing can be conducted through several genetic methods, including PCR, followed by immensely parallel sequencing.

The utilization of the method is different according to the donors and organs to be transplanted. Various benefits such as high procedural efficacy, real-time data interpretation, small processing time, and multi-sample test are provided by molecular assays. The sequenced-based molecular assay segment held the maximum revenue share during the forecast period.

By Application Analysis

The Diagnostics Segment Holds the Highest Market Revenue Share During the Forecast Period

Based on the application, the global HLA typing transplant market is categorized into diagnostics and research. Among these, the diagnostics segment accounted for the maximum market revenue share in 2022 with a CAGR of 6.7% during the forecast period due to the outsourcing of laboratory services by hospitals and transplant centers and a merging trend among diagnostics laboratories.

Transplant centers and hospitals collaborate with diagnostic labs to assume diagnostic methods. Diagnostics can be used to diagnose diseases such as Behcet’s disease, rheumatoid arthritis, and narcolepsy, which pave the way to quicken the market for HLA typing. The research segment is anticipated to show significant growth during the forecast period.

By End-User Analysis

The Hospitals & Transplant Centers Segment Dominated the HLA Typing Market

Based on the end-user, the global HLA typing transplant market is divided into academic institutes, commercial service providers, hospitals and transplant centers, and others. Among these, the hospitals and transplant segment is anticipated to hold the highest revenue share of 56% during the forecast period.  In North America, there are approximately 147 hospitals and transplant centers for liver transplants.

Owing to the availability of advanced medical devices and skilled professionals that enable treating patients efficiently and providing accurate results on time. Human leukocyte antigen typing is mostly used in hospitals and transplant centers for transplant organs.

The academic institute’s segment witnesses the maximum growth in the market during the forecast period due to the rising services by academic institutes.

Key Market Segments

By Product

• Instruments
• Reagents & Consumables
• Software
• Services

By Technology

• Molecular Assay
• Non-Molecular Assay
• Sequenced-based Molecular Assay

By Application

• Diagnostics
• Research

By End-User

• Hospitals and Transplant Centers
• Academic Institutes
• Commercial Service Providers
• Other End-Users

Drivers

Increase in the Demand for Organ Transplantation to Drive the HLA Typing Market Growth

The increasing burden of infectious diseases, combined with the rising number of transplant processes, is the major factor propelling the market growth. According to statistics, the distribution of organ transplants across the world displays that kidney transplants are by far the maximum common procedure.

In 2021, the projected numeral of organ transplants globally was over 144 thousand, nearly two-thirds of which existed kidney transplants. However, thousands of life-saving organ transplantations are achieved each year. Increasing public consciousness of organ donation allows the market to develop.

Rising donation methods for transplantation are also anticipated to drive the market’s whole growth. Further, the main key players are highly focused on product launches, along with the regulatory bodies and governments. They support the market players by the benefit of product adoption, the significant factor estimated to propel the market growth.  Additionally, the increasing geriatric population and technological advancements is projected to drive the growth of the market.

Restraints

High-Cost Hamper Market Growth

The high cost related to the equipment of organ transplants, such as PCR and NGS, reduces the market growth. The vast gap between the organ donor and organ acceptor required for transplantation restricts the market growth. Undesirable policies for organ transplant is expected to hamper the market growth. Stringent government rules for organ transplantation cloud restrain the market growth of the HLA typing market.

Opportunities

Technological Developments are projected to Provide Lucrative Opportunities for the Market

Technological innovations will further offer various opportunities for fueling market growth. Developments in healthcare facilities among developing countries pose significant business growth prospects for the market. Additionally, increasing public awareness and investments in product innovation is also expected to deliver numerous opportunities for the HLA typing market.

Impact of Macroeconomic Factors

Macoeconomic trends affect the HLA Typing market to a great extent. Inflation, for example, is one factor with a considerable influence on the market. Inflation is accompanied by marked increase in cost of living. With increasing costs of the bare necessities, consumers experience financial strain.

This impacts customer behavior as well, with customer preferring to delay purchases of what they deem to be unnecessary. Healthcare is also put off due to tight budgets. This can impact the HLA Typing market since patienst may choose not to seek medical help when they need it.

Latest Trends

The Increasing Demand for Diagnostic Goods is the Global Trends in the Market

The increasing demand for private, public, and diagnostic goods for enhanced HLA research is a global trend in the market. A rise in the number of transplant procedures and an increase in the incidence of infectious diseases is the trend in the HLA typing market. A major trend in the market is the development in HLA diagnostics is the introduction of molecular diagnostics methods such as NGS and PCR.

Regional Analysis

North America Dominates the Global HLA Typing Market During the Forecast Period

North America accounted for a significant HLA typing transplant market revenue share of 47.9% due to the enhancing demand for organ transplants and increasing government activities to promote the advancement of programs for organ donation and transplantation.

Attributable to the high approval of advanced technologies, the rising prevalence of the disease is anticipated to drive the growth of North American regions. Europe is estimated to hold the second-largest market revenue share of 28.6% during the forecast period.

Asia-Pacific is anticipated to register a CAGR of 8.6% in 2022 due to the enhanced infrastructure of the healthcare facilities, improving growth of economic factors, and well-designed reimbursement policies resulting in a positive impact on market growth.

Key Regions

North America

• US
• Canada

Europe

• Germany
• France
• The UK
• Spain
• Italy
• Russia
• Netherland
• Rest of Europe

Asia Pacific

• China
• Japan
• South Korea
• India
• New Zealand
• Singapore
• Thailand
• Vietnam
• Rest of APAC

Latin America

• Brazil
• Mexico
• Rest of Latin America

Middle East & Africa

• South Africa
• Saudi Arabia
• UAE
• Rest of MEA

Key Players Analysis

The key players in the market are mainly fragmented owing to the increase in the number of product launches by biotechnological and pharmaceutical companies. The increase in progressive biotechnological companies increases genetic testing, among others.

Some of the prominent key players in the HLA typing market include F. Hoffmann-La Roche Limited, Thermo Fisher Scientific Inc., Bio-Rad Laboratories Inc., Pacific Biosciences, and other key players.

Market Key Players

• Thermo Fisher Scientific Inc.
• Bio-Rad Laboratories Inc.
• Qiagen N.V.
• Illumina Inc.
• Hoffmann-La Roche Limited
• Pacific Biosciences
• Luminex Corporation
• TGB Diagnostics Limited
• Other Key Players

Recent Developments

• September 2023: Illumina Ventures, a investment subsidiary of Illumina, invested US$ 15 million in Broken String Biosciences, a firm speicalising in genomics mapping. Broken String’s mapping platform does not make use of PCR Chain method, instead measures the breaks between DNA double strands.
• October 2023: Pacific Biosciences introduced PacBio WGS Variant Pipeline, a platform for whole genome data sequencing. This software is the most complete seconadary analysis pipeline in the market for human whole genome sequencing (WGS).

Report Scope