Market.us announces publication of its most recently generated research report titled, “Global Nerve Repair and Regeneration Market by Type (Nerve Conduit, Nerve Wrap, Nerve Graft and Nerve Cap), By Indication (Direct Nerve Repair/Neurorrhaphy, Nerve Graft), and by Region – Global Forecast to 2028.”, which offers a holistic view of the global nerve repair and regeneration market through systematic segmentation that covers every aspect of the target market.

The global nerve repair and regeneration market is projected to be US$ 4,934.9 Mn in 2018 to reach US$ 8,210.0 Mn by 2028 at a CAGR of 5.2%.

Injuries and damage to the peripheral nervous system still poses the gravest challenges for surgeries. Severance of major nerve trunks causes total or subtotal loss of sensory and/or motor function of the body and can cause considerable disability. In spite, of technological advancements in microsurgical procedures, there is still a significant gap with regards to complete restoration of patients.

Healing is one of the major biological problem when a nerve is injured, since the nerve cells do not multiply after injury. Instead, each severed neuron extends new peripheral processes to restore its original axoplasmic volume, lost with amputation of the original axon. This cellular repair contrasts brightly to the intense proliferation of fibroblasts and endothelial cells at the site of injury, as well as Schwann cells in the distal segment. The results of nerve repair have today reached a plateau, where functional recovery is still unsatisfactory and the surgical techniques cannot be further refined.

Primarily there are three degrees of nerve injury: Neurapraxia is often the result of a compressive or crush injury to the nerve where conduction is blocked due to myelin damage, resulting in a focal conduction block without Wallerian de-generation as the axon itself remains intact with recovery generally evident in three to six weeks when myelin continuity is restored. The complete interruption of axons is termed axonotmesis. Neurotmesis is the complete physiologic transection of axons as well as all supporting tissue. Neurotmesis results in changes within the nerve cell body and regeneration with a variable recovery course.

After nerve injury, muscle atrophy occurs at the motor endplate, followed by fibrosis. If reinnervation does occur, both old and new motor end plates will be activated. Although the muscle is atrophied and fibrotic, it can remain viable for up to eighteen months; however, if reinnervation does not occur within one year, the chance of functional recovery diminishes. Patient age is the most important factor to consider in evaluating the success of nerve recovery following repair while the level of injury also plays a role, with distal injuries having better recovery results than proximal injuries. Neuromodulation and Neurostimulation are novel techniques used for nerve repair and regeneration, as opposed to costly surgeries.

Both, neuromodulation and neurostimulation encompasses the application of targeted electrical, chemical and biological technologies to the nervous system in order to improve function and quality of life. The appropriate therapy (low level electrical pulses or micro-doses of medicine) are targeted to nerves along the spinal cord to block pain signals to the brain. It alleviates or lessens pain without putting patients into excessive sedation. It is an FDA approved procedure, wherein patients can also remove implants. However, currently neuromodulation does not guarantee reimbursement coverage.

More importantly, existing and emerging neuromodulation treatments also include application in medication-resistant epilepsy, chronic head pain conditions, and functional therapy ranging from bladder and bowel or respiratory control to improvement of sensory deficits. Technical improvements include a trend toward minimally invasive (or noninvasive) systems; as well as smaller, more sophisticated devices that may have automated feedback control, and conditional compatibility with magnetic resonance imaging. It has been investigated for other chronic conditions, such as Alzheimer's disease, depression, chronic pain, and as an adjunctive treatment in recovery from stroke.

Neuromodulation Techniques include:

• Invasive electrical neuromodulation
  • Spinal cord stimulation
  • Deep brain stimulation
  • Other invasive electrical methods
  • Auditory brainstem implant
  • Functional electrical stimulation (FES)
  • Vagus nerve stimulation (VNS)
  • Hypoglossal nerve stimulation
  • Percutaneous tibial nerve stimulation (PTNS)
  • Occipital nerve stimulation (ONS)
  • Sacral nerve stimulation (SNS)
• Non-invasive electrical modulation
  • Transcranial direct current stimulation (tDCS)
  • Transcutaneous electrical nerve stimulation (TENS)
  • Electroconvulsive therapy (ECT)
• Non-invasive magnetic neuromodulation
  • Repetitive transcranial magnetic stimulation (rTMS)
  • Transcranial pulsed electromagnetic fields (tPEMF)
• Invasive chemical neuromodulation
• Intrathecal drug delivery systems (ITDS)

Global Nerve Repair and Regeneration Market Revenue (US$ Mn), 2018–2028  

Increasing incidence and prevalence of nerve injuries is expected to be the major factor driving the growth of global nerve repair and regeneration market.

Growing geriatric population and subsequent increase in neurological disorders amongst them is estimated to further augment the market growth.

Nerve Graft and Nerve Cap segment accounts majority market share in the Nerve Repair and Regeneration Market.

Global Nerve Repair and Regeneration Market by Formulation, 2018

On the basis of region, the market is segmented into United States, China, Europe, Japan, Southeast Asia, India and Rest of the World. The United States accounts for the majority share in the global nerve repair and regeneration market, followed by Europe. Emerging economies such as China and Japan are expected to register the highest growth rate over the forecast period.

The research report on the global nerve repair and regeneration market includes profiles of some of major companies such as LivaNova PLC, Boston Scientific Corporation, Medtronic plc, Abbott Laboratories, Nuvectra Corporation, Polyganics Holding B.V., Stryker Corporation, AxoGen, Inc. etc.

Key Market Segments:

Type

• Nerve Conduit
• Nerve Wrap
• Nerve Graft and Nerve Cap

Application

• Direct Nerve Repair/Neurorrhaphy
• Nerve Graft

Key Market Players included in the report:

• LivaNova PLC
• Boston Scientific Corporation
• Medtronic plc
• Abbott Laboratories
• Nuvectra Corporation
• Polyganics Holding B.V.
• Stryker Corporation
• AxoGen Inc.

For the Nerve Repair and Regeneration Market research study, the following years have been considered to estimate the market size: