Global Bone Graft Substitutes Market By Product Type (Allografts, Bone Graft Substitutes, and Other Product Types), By Application (Joint Reconstruction, Spinal Fusion, Craniomaxillofacial, Dental, and Other Applications), By End-User (Hospitals, Specialty Clinics, and Other End-Users), By Region and Companies - Industry Segment Outlook, Market Assessment, Competition Scenario, Trends, and Forecast 2023-2032

Report Overview

The global Bone Graft Substitutes market size is expected to be worth around USD 3.1 Billion by 2022 from USD 5.6 Billion in 2032, growing at a CAGR of 6.2%. during the forecast period from 2022 to 2032.

Bone graft substitutes refer to the materials that are used to replace or augment the missing bone in several neurosurgical, orthopedic, and dental procedures. The market growth is expected to be fueled by the rise in demand for synthetic substitutes and an increase in the number of product approvals by various regulatory authorities.

In addition, the market expansion is also driven by growing demand for the development of biocompatible bone grafts in order to reduce adverse reactions.

Key Takeaways

• The Bone Graft Substitutes Market is set to achieve USD 5.6 billion in revenue by 2032.
• The market will grow at a 6.2% CAGR between 2023 and 2032.
• The bone graft substitutes market size was valued at USD 3.1 billion in 2022.
• The allografts segment held the largest revenue share of 53.4% in 2022.
• The spinal fusion segment dominated the market with the largest share of 56% in 2022.
• The hospital’s segment held the largest revenue share of 49% in the global bone graft substitutes market in 2022.
• In 2022, North America had the highest market revenue share of 44%.
• Asia-Pacific is expected to have a revenue share growth of 21% from 2023-2032.
• In March 2022, the Osteo-P Synthetic Bone Graft Substitute (BGS) was introduced by Molecular Matrix Inc.

Driving Factors

Rising demand for the adoption of synthetic bone graft substitutes and the increasing geriatric population fuel the market growth

Owing to a wide range of benefits, the application of substitutes is growing exponentially. For instance, it decreases the complications in bone grafting procedures at the donor site. Over the past few years, these substitutes have been gradually used in dental implants. In addition, the substitutes aid in increasing the thickness and height of the jawbone, enabling the effective placement of the dental implants, which restore the normal dimensions of the jawline.

These benefits related to such products have raised the adoption of dental bone grafts and are further expected to drive market growth.

Furthermore, the market growth is enhanced by the increase in the aging population worldwide. It is a significant growth factor, as the incidence of orthopedic conditions such as fractures and osteoarthritis tends to increase with age.

Restraining Factors

High cost and regulatory challenges restrict market growth

The expensiveness of bone graft substitutes may be a barrier to their extensive use, especially in less developed countries, where the patients may not have the ability to afford such treatments or where the healthcare systems are not able to provide coverage for them.

Moreover, as bone graft substitutes are classified as medical devices, they must undergo rigorous regulatory approval processes before they are introduced to the market. This process can be costly and time-consuming. As a result, it can limit the introduction of new products and hampers market growth.

Product Type Analysis

The allografts segment held the largest revenue share of 53.4% in 2022  

Based on product type, the global bone graft substitutes market is divided into allografts, bone graft substitutes, and other product types. Among these, the allograft segment dominated the market with the largest share of 53.4% in 2022.  and is estimated to witness robust growth opportunities over the forecast period.

The adoption of an allograft is increasing significantly due to its properties, such as immediate structural support and osteoconductivity. Additionally, the positive patient results with the allograft products as well as several recent launches of allografts, have significantly contributed to the expansion of this segment. Moreover, allografts don’t need other surgery to harvest bone. This led to lesser surgery time, rapid wound healing, and higher success rates.

Application Analysis

The spinal fusion segment dominated the global bone graft substitutes market with the largest share of 56% in 2022

Based on application, the global bone graft substitutes market is divided into joint reconstruction, spinal fusion, craniomaxillofacial, dental, and other applications. Among these, the spinal fusion segment accounted for the largest revenue share of 56% in 2022.

This significant growth is mainly due to the rise in the adoption of bone graft materials for spondylosyndesis. In addition, the increasing geriatric population is susceptible to numerous orthopedic disorders. As a result, it is the major responsible factor for the expansion of this segment.

End-User Analysis

The hospital’s segment held the largest revenue share of 49% in the global bone graft substitutes market in 2022

Based on end-users, the global bone graft substitutes market is segmented into hospitals, specialty clinics, and other end-users. Among these end-users, the hospital’s segment dominated the global bone graft substitutes market with a maximum share. This growth can be highly attributed to the increase in number of qualified orthopedists in hospitals.

In addition, rising patient visits in hospitals for various joint reconstruction and spinal fusion surgeries are anticipated to boost the market growth. On the other hand, the specialty clinics segment is expected to witness the fastest CAGR during the forecast period owing to the growth in the number of specialty clinics worldwide. Moreover, the improving healthcare facilities in developing countries are likely to surge the segment growth in the coming years.

Key Market Segments

By Product Type

• Allografts
• Bone Graft Substitutes
• Other Product Types

By Application

• Joint Reconstruction
• Spinal Fusion
• Craniomaxillofacial
• Dental
• Other Applications

End-User

• Hospitals
• Specialty Clinics
• Other End-Users

Growth Opportunity

Advancements in technology and rising medical tourism offer significant growth opportunities

The advancements in technology have led to the development of innovative bone graft substitutes with improved safety, efficacy, and biocompatibility. These technological advancements include the use of growth factors, 3D printing, stem cell therapy, as well as tissue engineering techniques. The major key players in the global market significantly invest in research and development to increase their product portfolios, which can capitalize on these technological opportunities.

In addition, the rising medical tourism worldwide, particularly in developing countries, is likely to create numerous growth opportunities in the global market. These countries offer high-quality healthcare services at an affordable price. This is the main reason attracting patients seeking orthopedic treatments.

Latest Trends

Growing research and development activities & rising demand for minimally invasive procedures

There has been increasing investment in research and development activities over the past few years. Major companies are largely concentrating on the development of new products with improved biocompatibility, efficacy, and osteoconductive properties. The researchers are also involved in the exploration of the use of stem cells and regenerative medicine techniques for the enhancement of bone regeneration.

Moreover, there is a preferential shift towards minimally invasive procedures. They have gained huge popularity in recent years owing to benefits such as reduced pain, smaller incisions, shorter hospital stays, and faster recovery.

Regional Analysis

North America dominated the global bone graft substitutes market with the highest revenue share of 44% in 2022

Based on region, the market is divided into North America, Europe, Asia Pacific, Latin America, And Middle East & Africa. Among these regions, North America accounted for the highest revenue share of 44% in 2022. This regional growth can be highly attributed to the presence of high healthcare expenditure, advanced healthcare infrastructure, and a large patient population in this region.

In addition, regional growth is also influenced by factors such as a rising geriatric population and an increasing prevalence of musculoskeletal disorders. In addition, the market for bone graft substitutes in Asia Pacific is expanding as a result large population base, increasing disposable income.

Key Regions

• North America
  • The US
  • Canada
  • Mexico
• Western Europe
  • Germany
  • France
  • The UK
  • Spain
  • Italy
  • Portugal
  • Ireland
  • Austria
  • Switzerland
  • Benelux
  • Nordic
  • Rest of Western Europe
• Eastern Europe
  • Russia
  • Poland
  • The Czech Republic
  • Greece
  • Rest of Eastern Europe
• APAC
  • China
  • Japan
  • South Korea
  • India
  • Australia & New Zealand
  • Indonesia
  • Malaysia
  • Philippines
  • Singapore
  • Thailand
  • Vietnam
  • Rest of APAC
• Latin America
  • Brazil
  • Colombia
  • Chile
  • Argentina
  • Costa Rica
  • Rest of Latin America

• Middle East & Africa
  • Algeria
  • Egypt
  • Israel
  • Kuwait
  • Nigeria
  • Saudi Arabia
  • South Africa
  • Turkey
  • United Arab Emirates
  • Rest of MEA

Key Players Analysis

Emerging key players in the market are presently focused on implementing strategies such as partnerships, collaborations, mergers & acquisitions, new product launches, and competitive pricing. In addition, they are focused on spreading awareness and marketing their targeted products to capture a major portion of the market share.

Moreover, they are highly focused on geographic expansion to increase their market presence. This forms the competitive landscape in the global market and drives further market growth.

Top Key Players

• Medtronic Plc
• Zimmer Biomet
• Stryker Corporation
• Johnson and Johnson
• Smith and Nephew plc
• Baxter International
• Wright Medical Group NV.
• NuVasive Inc.
• Orthofix Holdings Inc.
• Integra LifeSciences
• Other Key Players

Recent Development

• In March 2022, the Osteo-P Synthetic Bone Graft Substitute (BGS) was launched by Molecular Matrix Inc. for its usage in the musculoskeletal system.
• In February 2022, Orthofix Medical introduced Opus BA, a synthetic bioactive bone graft solution used for cervical and lumbar spine fusion procedures.
• In 2020, DePuy Synthes launched VELYSTM Allograft for early-stage osteoarthritis of the knee.

Report Scope